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Histologically, there is neu-ronal loss, especially of the GABAergic medium spinyneurons (Joel, 2001) of the striatum
Histologically, there is neu-ronal loss, especially of the GABAergic medium spinyneurons (Joel, 2001) of the striatum. However, as a small-molecule inhibitor of Mdm2, it also has the poten-tial to inhibit or alter p53-independent effects of Mdm2 as well
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